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Then, the utility of this approach is demonstrated by determining L929 fibroblast cell viability in a more challenging matrix, collagen, an optical scatterer.
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We expect these methods to be optimized and validated for even more challenging matrices such as feces and plasma as done for single-target methods in the past [ 2].
Quantification becomes more challenging from soft matrices such as biological tissues because laser ablation from such materials is less controlled [ 12].
Extraction of antibiotics from solid matrices is more challenging as compared to aqueous media due to the complexity of solid matrices.
Applying the model of CA to predict the estrogenic potency of a real-world chemical mixture such as WwTW effluent is more challenging, given the complex chemical matrices involved.
However, its application to fully encapsulated cell-matrix systems is more challenging due to the requirements of complex mesh generations for encapsulated cells and non-uniform cell boundaries in three dimensions.
Lower signal intensities make recalibration based on matrix cluster signals slightly more challenging in this experiment.
More flexible models such as position weight matrix (PWM) motifs are more challenging in this context, partially because it is not clear how to avoid the use of arbitrary thresholds.
The use of fibers in pervious concrete is even more challenging due to high porosity and insufficient fiber-matrix bonding interface.
Due to the power constraint at each relay node (16), the source and relay matrices optimization problem (14)–(16) is much more challenging to solve when K≥2 compared with the case of K=1.
In those specimens, identification was a bit more challenging, but the presence of calcareous corpuscles in the somatic matrix was particularly helpful in establishing that the organism was a larval tapeworm.
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