The HS population represents a far more challenging target for inference of QTL effects than the pre-CC largely because its haplotype composition, inferred from a smaller number of genotyped markers on a more highly recombinant genome, is far more uncertain.
This is a more challenging regime to perform inference than is typically considered, as in this case the number of unknowns is growing rapidly with increasing observation length.
Thereafter, it becomes more challenging to carry out statistical inference.
Furthermore, tumors are heterogeneous and involve non-standard or unique disruptions or regulatory interactions, rendering GRN inference even more challenging [ 19].
Interpreting such relations in light of a particular search, a decision support problem or, even more challenging, the drawing of ad hoc inferences often leads to strange and erroneous results.
Despite these advantages, making causal inferences in observational studies is more challenging than in RCTs because of confounding by indication.
Our results show that i) model selection and parameter estimation improve with larger sample sizes and ii) consistent with previous work [ 19, 20], recent demographic events are more challenging and require substantially larger sample sizes for accurate inference.
The root network is of modest size, between 14 and 17 genes, a relatively easy case for inference algorithms and thus also a more challenging case for a boosting algorithm.
In the denouement of his book Kandel considers some of the more challenging aspects of the inferential brain; in particular, how we make inferences about other people, ourselves and our emotional states.
The retreat measurement is more challenging, as it requires tracking of the along-track position of the longwall equipment based on indirect inference from the adjacent rib-wall, as there are no stable along-track targets in a typical gate road.
