Seven examples are given here, beginning with simple design-based remedies and progressing to more challenging examples including the model-based remedies of mixed-effects modelling, generalized linear mixed models, state-space models, and geostatistics.
"Obviously, it'd be much more challenging, for example, if Argentina had their guys," said Kobe Bryant, who had 15 points.
"Where business has been more challenging, for example, on the West Coast, we have been working out inventory issues month by month on a case-by-case basis," he said in a written response to questions.
The final madman represented was the Polish-American pianist and composer Leopold Godowsky, whose 53 Studies on Chopin's Études render the difficult pieces even more challenging by, for example, transferring virtuoso passages in the right hand to the left and incorporating snippets of other études, as in his transcription of Chopin's "Black Key" Étude (Op. 10, No. 5).
Examinees scoring high on a construct might receive more challenging items, for example.
However, when faced with more challenging situations, for example, in patients with large or multiple stones and tapered or tortuous distal common duct, additional techniques such as mechanical lithotripsy may be utilized [ 2, 3].
However, other physical activity studies in patients with diabetes have set more challenging goals; for example, a minimum of 150 min/week of progressive mixed training [ 4], as well as offering a higher number of counselling sessions [ 3].
However, caution should be made for more challenging settings, as for example higher background activity concentration or small uptake volumes, where the differences are more pronounced.
In other cases, the conversion of biological data can be more challenging, due to for example the complex structure of many biological datasets, their often stochastic nature, the presence of missing values and scaling issues.
Regional effects are more challenging to measure, because, for example, the kinds of crime that happen in New York might differ from those in Texas.
