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An even more challenging aim is to understand the genetic basis of the large variation in DS phenotypes, which is probably caused largely by allelic variation in genes both on Hsa21 and on other chromosomes.
You can hold dumbbells or a barbell to make the exercise more challenging; aim to do 3 sets of 8 squats.
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The next phase will be even more challenging – aiming to.
In contrast, untargeted approaches are usually more challenging and aim at the detection of known and unknown metabolic products by (b) background subtraction and/or statistical investigation (e.g., Zhang et al).
The inclusion of filler images with unpredictable responses served to make the task more challenging and engaging, and aimed to make the rule less obvious in order to recruit learning in the automatic, associative system, rather than the explicit, rule-based system.
She said that working with these materials was far more challenging than normal fashion design since the aim was not just to create something that looked beautiful.
According to our view, Domb's procedure [44] appears more challenging for the surgeon and aims to better preserve the tendon, which may be helpful in younger and more active patients.
When the primary change is in arterial resistance, as when a vasopressor is deployed, the situation is more challenging since the intervention is aimed at generating a blood pressure increase, but the effect upon SV may be in either direction.
These studies have shown that aiming at more challenging targets, such as reducing blood glucose, lipids, and blood pressure to near-normal values, does not necessarily provide effective cardiovascular protection (3, 4 a finding that calls for rethinking our approach to therapeutic targets and to the roles of different drugs in their attainment.
However, analysis of family-based studies is more challenging, requiring achievement of two aims: partition of the information for association into between-family and within-family components, where only the latter is robust to confounding by hidden population structure [ 30], and allowance for correlations within family.
The consequent sensation of confidence is useful, in dealing with a game's more challenging stages, but also a worthy aim in itself.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com