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She added that from a democratic perspective, citizens are more challenging, active and questioning, and capable of holding the powerful to account when they have been to university, saying that hard evidence also shows more graduates are good for the economy.
By adjusting pH or using buffer systems, by adding taste masking or stability enhancing excipients or by using encapsulation techniques, even the more challenging active ingredients may potentially be incorporated into gelatin-based chewables.
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The lack of applications using a more challenging approach, involving active learning as well as student-centred and problem-centred learning, can be seen in the existing mobile applications.
Functional annotation of non-coding variation is more challenging and an active area of current research.
Even more challenging could be the active nature of the game — you don't walk around only to find Pokémon; once you've captured them, you also have to walk around in order to "evolve" them and increase their power.
Never is the skill of active listening more challenging than when no one is speaking--which is not uncommon in our field.
Furthermore, the structure-based rational design of the isozyme-selective inhibitor for an enzyme is even more challenging because of the conserved active site pocket shared by its isozymes.
Our findings have important consequences for public health initiatives, because adherence to a physical activity intervention program is likely more challenging for individuals who lack a biological drive to be active, and might even experience adverse effects in response to being physically active (47), than for individuals with a strong genetic predisposition to being physically active.
Determining activated GPCR states will often be more challenging then inactivate states, and the ability to use one active structure as a model for others, as well as recapitulating the activated function in the ligands, would have wide impact.
Predicting energy expenditure from physical activity is inherently more challenging in persons with chronic physical disabilities who use wheelchairs due to altered movement patterns and variations in metabolically active muscle mass.
However, Tanimoto-based screening is significantly more effective if attention is focused on the more challenging task of identifying structurally diverse sets of active molecules; this might limit the effectiveness of the BIN approach for scaffold-hopping applications.
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