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More cellular uptake was achieved after TiO2 exposure, particularly at 10 μg mL−1, presence of TiO2 resulted in more than 2-fold increase in cellular granularity compared with BiOBr.
Moreover, CD44-engineered mesoporous silica nanoparticles provided active target, which promoted more cellular uptake of DOX in the resistant cells and more retention of DOX in tumor tissues than unengineered counterpart.
The studies on cellular uptake and biodistribution indicated that the better antitumor efficacy of tSLNs was attributed to both the increased accumulation of drug in tumor and more cellular uptake by hepatoma cells.
We concluded that natural SPC had great advantages over traditional PVA with less burst drug release, more cellular uptake, and higher anticancer efficacy.
The results confirmed that ABP-SS contributes to more cellular uptake of complexes in HepG2 cells.
Taking advantage of the high density of DNA on AuNPs, DNA AuNP conjugates gain more cellular uptake.
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The needle-shaped HCPT-PND, which with longer blood retention time and more effective cellular uptake, makes it possible to accumulate drug in tumor tissues and exhibit higher cytotoxicity.
In addition, Pec-8PUH NPs could enhance cell cytotoxicity, shorten blood retention time (7.3-fold UA, 7.2-fold HCPT) and more effective cellular uptake than free drugs, which exhibited an obvious synergistic effect of UA and HCPT by the co-delivery.
More importantly, cellular uptake was significantly enhanced when cells were treated with Ad/PPSA in comparison to that with Ad/PPS (P < 0.05), suggesting that arginine graft increase cellular uptake.
Our studies showed that the conjugation of c-RGD peptides to the NPs resulted in 20 times more rapid cellular uptake and also enhanced constrained motion of the NPs about 13% higher than that of PEGylation.
Although pharmacological inhibitors (Table 3) can be used to inhibit internalization processes, these inhibitors are not completely specific and may suppress more than one cellular uptake pathway.
More suggestions(15)
more widespread uptake
more cellular imaging
more accurate uptake
more rapid uptake
more focal uptake
more cellular debris
more cellular connectivity
more general uptake
more cellular injury
more equitable uptake
more recent uptake
more cellular fiber
more cellular frequency
more cellular damage
more selective uptake
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