Such studies are dependent on the development of more complex cellular models of the human central nervous system in vitro, which combine neurons, astrocytes, oligodendrocytes and microglia.
There are obvious applications for using iPSC lines generated from individuals with genetic forms of AD to produce more complex cellular models in which familial AD neurons are used as initiator cells for the disease, whereas neuronal and non-neuronal cells of other genotypes are used to study their roles in disease progression.
One strategy to improve the rate of success of new cancer drugs transitioning into the clinic would be to more closely align the cellular models used in the early lead discovery with pre-clinical animal models and patient tumors.
Malten was able to drastically reduce the cell survival of all cell lines tested, showing interesting differences in terms of responsiveness and suggesting the presence of peculiar molecular properties that may render some cellular models more susceptible.
Then, both a CHKA stable inhibition as well as a simultaneous inhibition of the enzymes involved in both the biosynthetic as well as catabolic pathways could be more appropriated in these cellular models to obtain a stronger biological effect.
Thus, the prospect of engineering DA neurons from stem cells has attracted considerable interest as it could provide opportunities for more advanced in vitro cellular models, allowing refined methods for drug development, and for cell replacement in patients with Parkinson's disease.
To shed more light on suitability of cellular models of nervous origin for neurotoxicity screening, the objective of this study was to compare the sensitivity to genetic damage induction of two nervous cell lines.
Complete organisms such as C. elegans have more morphological features than simple cellular models.
For instance, the limitations inherent in the use of human samples (e.g. myocardium) are being overcome, at least in part, through the use of improved animal and cellular models that more closely resemble human physiology, including pigs and other large animals, and patient-derived iPS cells.
Cellular models that are more representative of fatty acid partitioning within the human liver are required to help elucidate the causes and progression of NAFLD.
