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As a consequence, genes can differ significantly in their taxonomic distributions, with more broadly conserved genes having 'housekeeping' functions and less conserved genes being responsible for the phenotypic differences observed between organisms.
Finally, interrogation of stem-cell-derived motor neurons produced from ALS patients harboring a repeat expansion in C9orf72 indicates that at least a subset of these changes are more broadly conserved in ALS.
Axis formation is a much more broadly conserved feature of meiosis; it is shared by all known sexually reproducing species.
However, we identified a more broadly conserved motif in Alpha- Beta- and Deltaproteobacteria as well as Cyanobacteria and Firmicutes.
Due to poorer quality alignments for more distantly related species, this procedure misclassified several more broadly conserved miRNAs as mammalian conserved.
Therefore, mammalian conserved miRNAs that aligned with >90% homology to a mature miRNA from chicken, frog, or zebrafish, as annotated in miRBase release 21 (Kozomara and Griffiths-Jones, 2014), were re-classified as more broadly conserved.
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In the best-studied case of Salmonella typhimurium, there are more than 40 components involved in various aspects of flagella function, but only about 24 of them are broadly conserved in other motile bacteria and are functionally indispensable [17].
However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs.
Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection.
This cross-kingdom communication is broadly conserved, providing a compelling argument for its adaptive value.
Although the genomic pattern of nucleosome positioning is broadly conserved, quantitative aspects vary over evolutionary timescales.
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