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This would be consistent with the more broad responses found in avian TLR1/2 heterodimers, possibly in response to a more diverse set of pathogens.
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However, a more broad immune response which includes efficient antibodies against the influenza surface proteins as well as induction of CD8 T cells – as accomplished by live vaccines - would be desirable.
Our work suggested that senescence might be a more broad stress response that could also protect against cancer.
However, co-expression of two or more pheromone receptors in the same olfactory neuron could also explain the more broad in vivo responses [23].
However, it should be kept in mind that control of HIV may require broad responses to multiple epitopes, and eliciting potent epitope-specific CD8 T-cell responses requires more than MHC compatibility.
They have offered two broad responses to such claims.
More broad questions remain too.
I wanted something bigger, something more broad".
Make your project more broad.
Of even more broad-reaching importance is the impaired response to parenterally- [20], [21] and orally- [22] administered vaccines seen in those with intestinal or tissue invasive helminth infections.
Overall, use of four peptide sets detected significantly broader responses; six more participants showed Gag T-cell recognition when stimulated with four sets of Gag peptides compared to when only clade B peptides were evaluated, (13 of 21 responders compared to 7 of 21 respectively), table 2 and figure 3b.
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