Criteria for the erosive disease were the presence of one or more bone erosions, defined as loss of cortical definition of the joint and recorded in proximal interphalangeal joints, metacarpophalangeal joints, carpal joints, wrist joints and metatarsophalangeal joints.
Although the predictive validity of PDUS synovitis for structural damage has not been well described in patients with early RA, Kawashiri et al. had demonstrated patients with early RA with PDUS subclinical synovitis were associated with more bone erosions [ 75]. (ii) Patients with Established RA.
This limitation has been an obstacle to substituting MRI for XR in clinical trials, as articular cartilage loss is at least as important, if not more, as bone erosion in determining long-term disability in RA [ 8], and suppressing bone erosion does not always ensure that cartilage loss has been suppressed as well [ 2].
ACPAs may develop before the onset of clinical RA 22 23 and are associated with more severe and erosive disease, including bone erosion.
Site-by-site analysis of the CT scans also showed that joints with bone erosion were more likely to have NBF than those without erosion (Table 3).
This observation highlights the need for gaining a better and more detailed understanding of how bone erosion affects the sensory system.
As shown in Figures 2 and 3c,f, bone erosion was more marked in Mmp8-/ mice than in wildtype mice (P = 0.04 by Mann-Whitney U test).
For example, Gheita et al. demonstrated that bone erosion was more prevalent in gout patients with metabolic syndrome compared with those without metabolic syndrome [ 27].
Those joints with bone erosion were more likely to be affected by all features of NBF compared with non-eroded joints.
Patients with RA and RAMRIS-reported synovitis, bone oedema and bone erosion were more likely to have plantar plate pathology present at the fourth and fifth MTP joints compared to the second MTP joint.
