Sentence examples for more bone destruction from inspiring English sources

Similarly, increasing β leads to more bone destruction, higher tumour burden and faster tumour progression.

Pain occurs at rest if the condition is left without management, causing more and more bone destruction.

In a lipopolysaccharide-induced inflammatory bone resorption model, IRF-8-deficient mice exhibit enhanced osteoclast formation and more dramatic bone destruction than wild-type littermates.

We found larger numbers of osteoclasts and more severe bone destruction in joints of IFN-γR KO mice than in joints of wild-type mice.

The OVX group treated with DCA had an earlier onset of disease, more frequent and more severe arthritis, and more synovitis and bone destruction compared with the sham-operated group treated with DCA, which had intact estrogen production.

However, there was more bone and cartilage destruction in the absence of IFN-γ + IL-4, suggesting a more aggressive phenotype of IL-17 responses in the absence of both Th1 and Th2 responses.

This certainly seems probable since a recent study has demonstrated that prostate tumours-expressing high levels of Dkk-1 produce more extensive local bone destruction compared to controls that express lower levels (Hall et al, 2005).

The marked reduction of CIA in mice, the changes in synovial tissue from mice with CIA after IFN-β therapy, and the effects on synoviocytes from RA patients all support the view that IFN-β treatment has immunomodulating effects and might have a beneficial effect on joint inflammation and, perhaps more importantly, on bone destruction in RA patients.

Collectively, these findings suggest that Tie2-Fc is more advantageous for suppressing inflammation than VEGF-Trap and that VEGF-Trap is more advantageous for preventing bone destruction than Tie2-Fc.

CIA in D/J.gp130F759 was more severe, with greater bone destruction, than the control mice.

Mice lacking Bid display increased arthritis associated with more inflammation, pannus formation, bone destruction, and infiltrating leukocytes.