Ultimately, more realistic biological models of tumor development and a more comprehensive understanding of the relationship between individual mutations will be necessary to classify mutations according to their role in the underlying process of tumor progression (reviewed in [ 75]).
Naturally, more biological realistic models should now be developed, where insertion is not completely prevented and where non-persistent genes deletion could have a distribution of fitness effects.
All of these authors have attempted, in one way or another, to produce formal models that can integrate the effects of cultural inheritance into more standard biological models of evolution.
Being a small city that lacks space for conducting large-scale functional genomics projects on animal models such as the mouse, Hong Kong obviously needs initially to focus on more handy biological models.
The models with both marginal and interaction effects may represent more common biological models.
Given the complexity of this process, more elaborate biological models are needed to account for the role of networks of mutations in this competition between cell lineages [ 74].
Although we can relax the conditions of PEDI so as to support more generic biological models by not requiring a model to have the form described by Equation (3), the efficiency and the accuracy of the model decomposition might decrease.
The advantage of information theoretic measures [ 38- 40] is that the concrete underlying dynamics does not need to be specified precisely, instead, a qualitative model is enough to gain principle insights into common working mechanisms with regard to more elaborate biological models.
He also states that he sees the role of psychotherapy as central to the practise of psychiatry – and in this he dissents from the more mainstream "biological" model of treatment that has been in the ascendancy since the 1970s.
Nevertheless, for more general biological modeling, process maps are likely to be of unmanageable size due to combinatorial complexity.
