In addition to having a role in climate change, nitrogen has a huge, probably more important biological impact through its presence in fertilizer.
Genetic association studies have typically placed heavy emphasis on coding SNPs, with the idea that these are more likely to have biological impact than noncoding SNPs.
Nevertheless, for more fundamental conclusions of the biological impact of these kinases, a more detailed investigation is needed, e.g. by testing several independent shRNA sequences directed against the targets identified to rule out off-target effects.
Based on this, it would be more appropriate to study the biological impact of induced P-cadherin expression in a model in which mice develop basal-like cancers, such as that recently described by McCarthy and coworkers [ 77].
To gain more information on the potential biological impact of the non-synonymous mutations in RTKs listed in Table 3, we searched for the affected domains using the Nucleotide database from NCBI and the String database.
These genes and their potential translational products need to be studied more extensively to understand their full biological impact on M. leprae.
A more thorough understanding of the mechanisms and the biological impact of the reported associations with overall variance in gene expression represent important areas for future research.
Whereas blocking the activity of one, or even more, inflammatory factors may not have a significant biological impact owing to biological redundancy, inhibiting a signaling hub that connects several cytokine-activated pathways (e.g., inflammation, apoptosis, and differentiation), such as p38 MAPK, has more therapeutic promise for the treatment of low-risk MDS.
They are especially significant as ERBB4 overexpression is more frequent than ERBB4 mutations in cancer, but the biological impact is uncertain.
