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With the WikiPathways web service, we aim to encourage database developers to integrate pathway information into their online data presentation to provide more biological context.
Additional information captured in this column provides more biological context to the GO annotation.
In a more biological context, the multiple CRDs of the membrane-bound DC-SIGN tetramer must interact with multiple glycans displayed on a membrane surface.
The GOC has introduced an Annotation Extension field to capture additional information that provides more biological context to the GO annotation (GAF 2.0, http://www.geneontology.org/GO.format.gaf-2_0.shtml).shtml
In a more biological context, the present result also suggests that the IL-15-dependent expansion and maintenance of memory T cells are independent of TNF blockade.
However, were that to be true [and to hold for some other miR-like hairpins in the genome], it would only make our data more interesting and provide more biological context (e.g., it might tie in with the observation that some transcription factors bind double-stranded sequences).
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Given a TF and its activated and repressed target genes defined using ChIPx and gene expression data in one or more biological contexts, ChIP-PED searches for other contexts in which the TF is likely to be functionally active.
To further confirm this activity in a more relevant biological context, we tested the ability of ORF73 to mediate the poly-ubiquitination of endogenous RelA following stimulation with TNF.
Such an approach could not only provide more robust biological context, but also leverage data from cohorts that may not be large enough to yield high numbers of genome-wide significant GWAS results for complex traits such as allergic rhinitis.
To test its versatility in detecting diverse PTM groups in a more complex biological context, we next applied PTMClust to analyze a large-scale PTM dataset taken from analyses of yeast protein complexes (LC-MS/MS spectra only) (Krogan et al., 2006) using SIMS.
This construction allows the weights to refine clusters under more meaningful biological contexts.
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