Unmodified dendrimers with surface cationic groups may elicit some toxic manifestations, and the surface engineering of dendrimers to mask these cationic surface groups plays a critical role in their possible clinical applications by rendering them a more biocompatible surface with less toxicity.
To make engineered nanomaterials more biocompatible, both surface coatings and covalent surface modifications have been incorporated.
Our results showed that use of surfactant decreased particle size possibly by coating surface and providing steric hindrances during particle growth but at the same time made surface more biocompatible thereby providing antagonistic effect between size and surface property on toxicity.
The deposition of ethylene glycol plasma polymer-coated nanoparticles confers properties to the surface making it more biocompatible, which is beneficial in applications of SS316L as a blood-contacting implant (e.g. vascular stents, heart valves).
PEG is commonly used for NP surface derivatization to make NPs more biocompatible; however, our results indicate that the concerted influence of the PEG molecule length and NP surface charge determine the NP uptake, turnover, and toxicity.
That is why the possibility of applying to the surface of titanium implants more biocompatible coatings is still very important.
Meanwhile the SiO2 shell can be easily surface-functionalized and is more biocompatible for further application in biomedical uses [10].
Introduction of PEG onto the surface of nanoparticles protects against unwanted agglomeration, makes them more biocompatible, and decreases their nonspecific intracellular uptake.
Because the knowledge of proteins adsorbed onto vector surface could be useful in the screening of new, more efficient and more biocompatible liposomal formulations, the behavior of three CLs with different membrane charge densities was investigated.
The modified titanium surface, which is rough and porous, contains calcium phosphates and proved to be more biocompatible in vitro.
