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This hypothesis can be tested in a more appropriately designed clinical trial to assess whether there is a relationship between infection, inflammation and preeclampsia.
The means by which patellar tape can relieve pain may provide insight into the aetiology and risk factors for PFPS, thus allowing more appropriately designed treatment regimes and preventative strategies.
A more appropriately designed electrode that accommodates to the shape and size of peripheral nerves would not only obviate this problem, but would also reduce the procedural time required by the surgeons.
Striking the right balance between expanding existing data sets and developing new, more appropriately designed monitoring programs and metrics will be vital if measures of biodiversity change are to robustly support conservation decisions.
The translation from bench to bedside would certainly be improved if preclinical studies were more appropriately designed.
We do not suggest that treatments aimed at ameliorating oxidative stress may not have their place as therapy, but rather that better understanding of their interaction with other cellular processes may allow for more appropriately designed (and therefore more effective) treatment.
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In addition, internal controls are more appropriately custom designed for analyte control in assays with a clearly defined intended use and therefore are by definition assay-dependent.
Still, in most circumstances, while many substitution reactions1 (e.g. with a primary iodide) and especially 1,4-additions2 (e.g. with α,β-unsaturated ketones) tend to be far more rapid processes, the appropriately designed substrate can often benefit considerably from a copper reagent mediated 1,2-addition, not only in terms of yield but especially with regard to diastereoselectivity.
Hence, it is fitting to run this pioneering trial in Hong Kong which will inform more rigorous trials to be appropriately designed in the future.
Therefore, although we strongly agree with Drs. Ziogas and Roukos that caution should be used in the routine use of bevacizumab in treatment protocols, we think that more research studies that use appropriately designed protocols approved by an internal review board, with patient's written informed consent, should be encouraged.
The lack of greater achievement of lifestyle behaviors suggests a need for more access to and use of appropriately designed tools for weight loss (e.g. prescribed diet plans) and exercise (e.g. exercise equipment, aerobic exercise videos), and fitness facilities or exercise programs at community centers or school gymnasiums for effective lifestyle modification among minority individuals.
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