Sentence examples for more appropriate trials from inspiring English sources

Future studies on this field would take advantage of this meta-analysis to design more appropriate trials on HFOV in adult ARDS patients.

Therefore, to improve the use of conventional ventilation in the neonatal population and to better define the role of HFO in lung protective ventilation in adult patients, more appropriate trials are still needed.

Thus, a clinical highlight of the past year has been a renewed emphasis on designing and implementing more appropriate clinical trial methodology for evaluating disease-modifying treatment in AD.

Specific requirements are detailed in the Food and Drug Administration Amendments Act of 2007 [ 21], while, in 2007, the EMA enacted a new "Paediatric Regulation" which mandates greater and more appropriate clinical trial activity and reporting of data during the development of medicines intended for use in children aged 0-17 years [ 22].

The dichotomous outcome research model is more appropriate for drug trials, with very limited or no collateral benefits and targeted action.

Recently, more fine grained and validated test tools and protocols have become available for assessing thoracic motor function (Ellaway et al., 2007), which may be more appropriate for future trials when sub-clinical outcome measures are required.

Generic instruments are useful for comparing quality of life impact in populations with different diseases; however, disease-specific tools are generally more responsive and sensitive to disease-specific issues and are therefore more appropriate for clinical trials in which specific therapeutic interventions are being evaluated [ 10, 11].

Large oocyte donor database retrospective studies [ 17] and a number of methodologically more appropriate randomized clinical trials [ 21– 23] found no significant differences in the number of retrieved oocytes (total and mature), fertilization rates, embryo quality, and pregnancy rates, indicating that GnRHa trigger and hCG trigger provided equivalent outcomes in the recipients.

In this trial, we planned to recruit participants with PDS only, because a narrow and specific population will be more appropriate in a trial using efficacy design.

Although 3-year disease-free survival (3-years-DFS) using CT imaging is a commonly used endpoint in adjuvant setting, 18 month laparoscopy is more appropriate in this trial because of the restricted sensitivity of imaging modalities to detect PC at an early stage.

However, owing to the lack of data, we consider a safety and feasibility trial more appropriate before the start of a randomised controlled trial in which standard of care is compared with early oral nutrition.