Senior nurses had a more appropriate threshold for triggering interventions, whilst junior nurses' threshold for taking action was too low.
We propose that three SIRS criteria is a more appropriate threshold that defines those patients with clinically significant inflammation post cardiac surgery.
We believe that a serum potassium concentration ≤3 mmol/L represents a more appropriate threshold as this comprises a serious risk of arrhythmia [ 33].
Taking a more appropriate threshold of 0.5 for the Ka/Ks ratio as an indicator of positive selection [ 18], 644 pairs with a Ka/Ks value between 0.5 and 1 were also found.
We also noted how many would satisfy the same criteria but with P≤0.001, which has been considered to be a more appropriate threshold of statistical significance to reduce false positives.
The optimization of the training dataset required an extensive number of tests to select the more appropriate threshold value and the number of samples to be used in the learning phase of the classification process.
This has led to the suggestion that with more sensitive assays, 100 to 200 copies/mL might be a more appropriate threshold for concern than 50 copies/mL [ 8, 9] and guidelines now define virologic failure as a persistent plasma RNA of 200 copies/mL or more [ 23].
In children aged 6 72 months, a cut-off of 1 110 was proposed as predicting a 50% protection rate, and 1 330 predicted a 80% protective level, which may be a more appropriate threshold given the vulnerability of very young children to serious influenza-related complications.
