The multivariate model 2 is more appropriate for construction of a predictive model for protein expression, as it considers the combined effect of all miRNAs and thus weighs the contributions of the individual miRNAs to obtain optimal prediction.
We believe that such a predictive approach is more appropriate for analysing risk, in general and for the health care area in particular, as there is only one level of uncertainty, stemming from lack of knowledge.
4 7 The use of predictive biomarkers promises a more appropriate choice of treatment; it can also help to rationalise funding decisions, avoiding costs of futile treatment and of adverse events.
In some clinical contexts other objectives may be more appropriate, such as estimation of the positive and negative predictive values, or area under the ROC curve.
However to improve the predictive value, weekly data in different locations would me more appropriate especially in the highland where environmental factors can vary greatly between valleys and where precipitations are non homogenous through the month.
Moreover, the predictive value of global rating scales has proved to be more appropriate than just counting specific behaviors [ 15, 21].
If the aim of analysis is to identify gene expression patterns predictive of clinical behaviour then a supervised approach seems to be more appropriate.
In addition to being more predictive of survival at the lower end of the scale, the AKPS may be more appropriate than the other performance status scales in settings outside of cancer.
Identification of functionally relevant predictive biomarkers for radioresponse in prostate cancer would enable radioresistant patients to be directed to more appropriate treatment options, avoiding the side-effects of radiotherapy.
Furthermore, the mixture model (Model 2) had a consistently higher predictive ability than the conventional non-mixture model (Model 1), indicating that mixture models are more appropriate to analyse this type of data.
