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∘ Moderate (Rankin 3): balance training/standing, global strengthening, therapeutic gait, adaptation to orthoses and walking aids, spasticity control, functional speech/adaptation to alternative communication resources, improving swallowing skills, independence in activities of daily living, cognitive-behavioral interventions to shape more appropriate outcomes and post discharge plans.
∘ Moderate (GCS 9 12): balance training/standing, global strengthening, therapeutic gait, adaptation to orthoses and walking aids, spasticity control, functional speech/adaptation to alternative communication resources, improving swallowing skills, independence in activities of daily living, cognitive-behavioral interventions to shape more appropriate outcomes and post discharge plans.
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This intermediate outcome was used in the analysis because patients in our study population have not been followed over a long-enough time period to allow for a more appropriate outcome to be measured.
23 The authors argued that waist circumference is not dependent on lean body mass and is therefore a more appropriate outcome when studying effects of physical activity.
Quality of life maybe a more appropriate outcome of interest than health status since it may take years to change health status through lifestyle interventions.
Future research should focus on developing more appropriate outcome measures, health economic methods, and exploring the use of quality of life or capability measures to determine effectiveness from a more holistic perspective.
Finally, QOL is a more appropriate outcome for chronic conditions, and together with our lack of more frequent study visits and longitudinal assessments, we did not include baseline scores in our analyses.
In addition, more appropriate outcome measures than pCR should be defined for 'luminal' tumours, that can be assessed in a replicable manner after the completion of local treatment, and that correlate robustly with relapse-free survival.
In a population that includes subjects who will never progress to AD and others who will progress to AD (such as a healthy population), it could be argued that conversion may be a more appropriate outcome.
At a trial steering committee meeting (and before recruitment ended), however, we decided to change the definition to 30% or more to reflect a more appropriate outcome for a community derived population with self reported knee pain (without changing the assumed event rates).
Despite the current tendency to focus on mortality rates after one year or longer, which are highly relevant to cost-effectiveness issues, short-term mortality may be a more appropriate outcome for determining whether new treatments correct the acute effects of severe sepsis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com