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Sørensen et al. (2015) concluded mortality to be a more appropriate endpoint than immobility, in order to account for toxicity rather than physical restriction.
Although RR remains the most common primary endpoint in phase II trials [ 8], disease stabilization may be a more appropriate endpoint for some agents and has also been associated with improved survival [ 10, 11].
Bertassoni and his co-workers proposed that a more appropriate endpoint to evaluate the effectiveness of remineralization should be associated with the recovery of the mechanical properties of the hydrated dental tissue, which is presumed to correlate well with its overall functionality [ 30].
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More appropriate endpoints may include mean OS, cure fraction, and OS rate at landmark time points.
The study also provided an insight into the intricacies that are the same and further ascertains that the mean overall survival, cure fraction, and overall survival rate at landmark time points represent the more appropriate endpoints.
Although PFS would have been a more appropriate primary endpoint in the treatment of locally advanced HNC, complete remission is useful as a means of avoiding unnecessary therapy for treatment decision-making after the completion of CRT.
Since, about 50% of death in GIST patients are not GIST-related, supported by our data, DSS may be a more appropriate clinical endpoint in GIST for outcome analyses.
Although PFS would have been a more appropriate primary endpoint in the treatment of locally advanced esophageal cancer, CR is a useful means of avoiding unnecessary therapy in treatment decision-making after the completion of CRT.
An exploratory analysis suggested that volume change may be a more appropriate primary efficacy endpoint in trials of CNS disease.
Our approach relies on the assumption that missingness is non-informative and, thus, may be more appropriate for some endpoints (infection/death) than for others (infection).
Instead of short-term mortality and need for RRT, we propose that the more appropriate short-term endpoints in studying AKI should be short-term mortality and RRT-free days, or even AKI-free days (similar to the endpoints in ARDS).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com