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DTCA has never been reliably shown to improve compliance, lead to more appropriate early diagnosis of under-treated conditions, or prevent hospitalizations and serious disease consequences [ 8].
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We would submit that these factors suggest that the STSS performs better in this population and overall would be a more appropriate early-assessment triage rule.
Moreover, late biopsies (e.g. after 2 years) are much more appropriate than early biopsies (i.e. after 6 months).
We are making a targeted set of changes to make it more appropriate for early-stage..
6 Consequently, it may be more appropriate for monitoring early response to treatments.
Our study population therefore is more appropriate for finding early breast cancer biomarkers than all previous studies where mostly symptomatic cases were included.
A quantitative approach might be more appropriate in the early response of PET to reduce the false-positive rate or decrease the inter-observer variability in interpretation [ 14- 16].
This helps in predicting and identifying the treatment failure and to switch to a more appropriate treatment as early as possible, and could even reduce overall treatment costs.
It should be also noted that heterogeneous multi-component chemistry is more appropriate for describing early symmetry breaking processes, since prebiotic environments have likely been highly chemically diverse [ 27, 33, 62].
A study design with the first examination after a few minutes or hours after birth and several repeated examinations just a few hours apart could have been more appropriate to detect early postnatal changes in TDI velocities.
Since the rapid acquisition of resistance probably represents a physiologic mechanism of adaptation at the multicellular level and not a stable genetic change [ 18], the spheroid model seems to be more appropriate to study early occurrence of acquired drug resistance in solid tumors than monolayer cell cultures [ 15].
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