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For this reason we chose to use the DREAM challenge data simulator (GeneNetWeaver) to provide a more appropriate dataset for the assessment of this method.
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Appropriate criteria are (i) the Akaike Information Criteria, AIC, which is wildly used or (ii) the Bayesian Information Criteria, BIC, which is more appropriate for datasets with more than 46 data points [ 11, 26, 27].
Analyzing the same datasets but using different similarity measures, shown in the Supporting Material [Additional file 16: Fig. S12(a)], may lead to a different conclusion, namely that a particular similarity measure is more appropriate for one dataset compared to another.
Since UA recall is more appropriate for unbalanced datasets, statistical significance over the baseline is determined using a one-tailed test (difference of proportions) over the UA recall values.
It has been suggested that using clinical datasets for risk model development is more appropriate than using administrative datasets.
Other techniques that extended the original methods were applied where more appropriate for the current dataset.
Reproducing the logistic regression analysis described in the Philippines study did demonstrate a trend towards delayed colonization with higher anti-Ply titres in our cohort (data not shown), but the Cox model remained a more appropriate analysis for the current dataset.
Therefore, Spark is more appropriate for the chosen Bristol open dataset.
Therefore, Spark proved to be more appropriate for the selectd Bristol open dataset.
For our dataset it appears more appropriate to use the 'per link' complexity, because the relative differences between Y2H and AP MSS.
Therefore, an evaluation on a proper in vitro dataset would be more appropriate to reveal the benefit of such physicochemical features in modeling TF-DNA interactions.
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