Exact(6)
A high level of multidrug resistance (MDR), which is defined as resistance to at least one antibiotic drug in three or more antibiotic classes (Cantón and Ruiz-Garbajosa 2011), was observed in all food sources (Fig. 1).
Bacterial isolates which showed resistance to two or more antibiotic classes were considered as multiple resistant.
We considered a strain as MDR if it was resistant to two or more antibiotic classes.
Multidrug-resistant: non-susceptible to one or more agents in three or more antibiotic classes.
ESBL-KP had significantly higher rates of resistance to gentamicin and trimethoprim-sulfamethoxazole as well as higher rates of resistance to 4 or more antibiotic classes (Table 1).
Defined by demonstrating resistance to three or more antibiotic classes (aminoglycosides, β-lactams, carbapenems, and fluoroquinolones) or producing either extended spectrum β-lactamases or Klebsiella pneumoniae carbapenemases [ 33].
Similar(54)
Kim et al. reported no association between disease severity and NAP1, although co-morbidity, age, and treatment with three or more antibiotics classes were all associated with severe CDI [ 21].
In the vast majority of cases the imipenem-resistant stains had a multidrug resistance phenotype, characterized by resistance to three or more other antibiotic classes.
Forty one (59.4%) of the 69 isolates were multiresistant (resistance to more than three antibiotic classes).
Clinical strains are frequently resistant toward more than three antibiotic classes including carbapenems, aminoglycosides, fluoroquinolones, cephalosporins, polymixins, tetracycline, and penicillins (Looney et al. 2009).
Exposure to more than two antibiotic classes during hospitalisation before VAP diagnosis was significantly associated with MDR aetiology in enter and backward stepwise regression analysis.
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