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The meningiomas (n = 4) were also more alkaline (pHi = 7.19 +/- 0.02) with a raised PME level but reduced PCr.
Ultimately, NHE-1 regulators alter transport activity by altering its affinity for intracellular H+ such that it is more active at a more alkaline pHi [ 69].
Similarly, cancer cell lines that are evolved to become drug resistant have a more alkaline pHi and a more acidic pH in subcellular organs when compared to the wild-type drug sensitive cells (HL60, K562, CEM, and MCF7) [ 38].
The astrocytomas (n = 7, grade II-IV) were significantly more alkaline (pHi = 7.08 +/- 0.03), and contained more PCr and PME, with respect to ATP, than normal brain at similar depth.
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At pHi 7, raising Ca2+ from 0 to 300 μM enhanced hSlo3 conductance by 6.6 ± 1.7-fold (200 mV), in contrast to the only 2.2-fold increase evoked by raising pHi from 7 to 9. Thus, Ca2+ activates hSlo3 much more effectively than alkaline pHi.
Furthermore, in NIH 3T3 fibroblasts expressing the Ha-ras oncogene, pHi was found to be significantly more alkaline than in identical cells not expressing the oncogene (Grunicke et al, 1988).
Conversely, redder hues respond to more alkaline soil, so add lime.
Guided by his edicts, locals could learn to drink a richer, more alkaline form of coffee.
Dissolving mineral dust in the ocean makes sea water more alkaline and able to absorb more carbon dioxide from the atmosphere.
The waters of Dublin, sitting on 300-million-year-old limestone, are even more alkaline and require even more roasting of the barley.
More magnesium in water will adversely affect crop yields as the soils become more alkaline.
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