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Breast cancer subtypes also vary in their degree of intra-subtype heterogeneity; more aggressive subtypes are more heterogeneous.
Notably, the achievement of pCR varied according to BC subtype, and the prognostic value was greatest in more aggressive subtypes.
In both studies, the molecular more aggressive subtypes were those associated with the expression of immunomodulatory and stem-like molecules.
Recent studies have attempted to control for tumor molecular subtypes, recognizing that more aggressive subtypes are more common in younger women.
Table 1 shows that the distribution of subtype and ROR-S score shifts toward more aggressive subtypes after adjusting for contaminating normal.
The North region presented with more aggressive subtypes (HER2-enriched and triple-negative), while the Central-West region predominated triple-positive carcinomas.
Similar(30)
The most common form is the classic-type (granuloma-like), though a more aggressive subtype known as the proximal- or axial-type has also been described.
The latter represents the more aggressive subtype with the poorest prognosis at diagnosis [2].
In cases showing features of more than one subtype, the more aggressive subtype was considered.
These findings have led to the conclusion that HER-2/neu overexpression is associated with a more aggressive subtype of cancer.
Hence, the shift of a molecular subtype towards a more aggressive subtype in the metastatic lymph node is a hypothesis-generating finding in line with recent publications [ 21].
More suggestions(15)
more virulent subtypes
more recent subtypes
more intrinsic subtypes
more detailed subtypes
more specific subtypes
more molecular subtypes
more aggressive reductions
more aggressive treatments
more aggressive species
more resilient subtypes
more frequent subtypes
more rare subtypes
more common subtypes
more favourable subtypes
more homogeneous subtypes
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