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Patients with t(4 14) MM demonstrate a shorter duration of remission and more aggressive relapses characterized by renal failure, cytopenia and extramedullary disease.
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For example, patients with basal-like breast cancers are prone to more aggressive metastatic relapse whereas patients with luminal A cancers generally have good long-term outcome [ 23, 25].
Previous ideas about why patients with TNBC have more aggressive tumors that relapse earlier than patients with other types of breast cancer have focused only on tumor cell-intrinsic properties.
But with the economy relapsing, more aggressive action is overdue.
Taken together, these findings support the concept that tumours tend to evolve towards a more aggressive biological phenotype at relapse.
The clinical value of our data may be both diagnostic and prognostic; patients with low anti-P1 IgM antibodies present with a more aggressive phenotype and earlier relapse.
HER2 expression is associated with more aggressive disease, increased risk of relapse and decreased overall survival, and is an important target for immunotherapy.
This heterogeneous group of tumors is more aggressive, with higher rates of relapse and worse OS.
The top curve in Figure 8 modifies the most aggressive case (dot-dash) by also including more aggressive intervention in the TB relapse population.
They tend to present later than Type I tumors and are more aggressive, with a greater risk of relapse or metastasis.
TN breast cancer had higher relapse rate and more aggressive clinicopathologic characteristics than non-TN in node-negative breast cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com