Exact(2)
The subsequent and more aggressive recurrence of the skin tumor had involved the superficial and deep cervical lymph nodes.
Patients with painful bone metastases could have different disease biology from asymptomatic individuals (more aggressive recurrence, rapid growth, higher disease burden, more lytic lesions), which could account for their poor prognosis.
Similar(58)
Most cancers are more aggressive following HR recurrence, there are no effective treatments for such cancers, and average survival following progression does not exceed 15 months [ 24].
We observed a more aggressive pattern of recurrence in patients with 9p-deleted tumours involving distant organs when first detected; in 11 out of 12 cases disease recurred distantly, whereas 3 out of the 4 patients with non-9p-deleted tumours had the first site of recurrence in the resected renal bed (P=0.026).
Generally the histology of a BCC does not change over time, although with recurrence, more aggressive BCC may be noted.
Compared with luminal A, luminal B is more aggressive and has higher recurrence rates and shorter survival times after relapse [ 4].
High levels of JAG1 are correlated with a more aggressive disease course and recurrence in human prostate cancers (Santagata et al, 2004) and indeed, a metastatic human prostate cancer cell line (PC-3 cells) expressed high levels of JAG1 protein.
6, 12, 17 Furthermore, this study showed that patients with more than three recurrent tumor locations had a worse post-recurrence survival compared with those with less involved locations, which could also be explained by the more aggressive behavior of multiple recurrences.
The presence of PNS is associated with increased risk of tumour recurrence, necessitating more aggressive treatment.
And a 2012 study found that women with breast cancer who got six or fewer hours of sleep a night seem to have an increased risk of recurrence and more aggressive cancers.
Thus, chemotherapeutics might spare CSC's and allow recurrence of more aggressive tumors.
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