Patients with painful bone metastases could have different disease biology from asymptomatic individuals (more aggressive recurrence, rapid growth, higher disease burden, more lytic lesions), which could account for their poor prognosis.
The prognosis for individual MDS patients varies greatly and ranges from relatively indolent disease with longer life expectancy to more aggressive courses with rapid progression to overt leukemia.
9 Given that we found no benefit with our intervention, which is more aggressive than most rapid intravenous rehydration strategies, our findings can be generalised to those who use smaller fluid boluses (such as 40 mL/kg).
The authors suggested that more aggressive tumours that exhibit rapid growth or changes in size are more likely to prompt earlier presentation.
Compared with the more common non-small cell lung cancer (NSCLC), SCLC is more aggressive and associated with rapid development of metastasis.
The more aggressive tumor behavior and more rapid rate of growth associated with hyperinsulinemia also may reflect cross-talk between the IR/IGF1R and an oncogene.
In the case of stroke, a plausible explanation for the decline of the one-year case fatality rate (and for the acceleration of mortality) is more rapid and more aggressive treatment for stroke in specialized stroke units, which were implemented on a large scale from about 2000 onwards [ 22].
Such cases may have had a more rapid progression and more aggressive tumour growth, which would have resulted in statistically significantly shorter DIs (data not shown).
When we compared grip strength data from SOD1 G93Adl B6 males and females, we found that, although grip-strength deficits occurred earlier in females, the rate of deterioration was more aggressive in males, suggesting a more rapid disease progression in males than in females (Fig. 2A,B).
If there is a subset of patients exhibiting distinct and more aggressive disease progression, for example a rapid loss of B-cell function, efforts should be made to promptly identify and intensify therapeutic measures, as they may be of particular benefit in these individuals [ 21].
Its more aggressive rivals, meanwhile, are growing at a rapid clip and becoming global.
