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The hypofractionated approach was chosen to improve logistic issues, patient compliance and provide a more aggressive radiation treatment.
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In this investigation polyNIMMO was subjected to gamma radiation which is a more aggressive form of radiation.
The authors postulated that the increased proliferation was a result of repopulation in the tumor pool or of the selection of astrocytoma cells with more aggressive phenotype by radiation.
This has led to more aggressive surgical resection and radiation therapy, thus requiring an accurate description of the anatomical boundaries of the tumour to guide therapy.
A next step is the application of functional imaging techniques, which can provide information on more aggressive parts or more radiation-resistant parts of the tumour.
This study was designed to determine the ability to intensify our prior approach utilizing hyperfractionated radiation and more aggressive consolidative chemotherapy.
This is because ITDD has less adverse effects than other pain treatments, so patients can endure more aggressive levels of chemotherapy or radiation.
We also evaluated whether breast cancers in patients who were previously treated with radiation have a more aggressive phenotype, and whether the clinical course differed from a sporadic group of breast cancer patients.
These effects counteract cell death, rendering the tumour more aggressive and decreasing the efficacy of radiation [ 9].
Therefore, we may consider more aggressive treatment, such as chemotherapy following radiation, for WHO grade II astrocytomas with a high risk of malignant transformation.
Elevated tumour growth in FGF8b expressing xenografts is based on stimulated proliferative activity and increased hypoxia tolerance, which may promote prostate tumour progression to a more aggressive phenotype associated with resistance to radiation and cytotoxic therapies.
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