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First, if aggressive primary prevention of CVD in patients with DM has reduced their mortality to a level comparable to those without DM, should we be targeting more aggressive primary preventative management to patients without DM?
Due to this imbalance, the patients with lymphatic mapping tended to have more aggressive primary tumors.
HCV recurrence disease have been described in three major forms: Acute or chronic recurrence and the less frequent and more aggressive primary cholestatic disease called fibrosing cholestatic hepatitis.
Our study provides no compelling support for more aggressive primary treatment of interval breast cancers than non-screen detected cancers with similar prognostic features.
Similar results were obtained for patients with two subtypes of primary cutaneous lymphoma, the indolent primary cutaneous follicle centre lymphoma (PCFCL) and the more aggressive primary cutaneous large B-cell lymphoma, leg type (PCLBCL) [ 47].
The identification of tumours with metastatic potential prior to the occurrence of detectable nodal spread would allow more aggressive primary treatment regimes to be instigated and directed at regional as well as local control.
Similar(53)
The study aimed at determining the dynamics of ER binding and differences between more and less aggressive primary breast tumors and metastases.
Melanomas in these sights may be intrinsically more aggressive leading to a primary presentation at a more advanced stage.
We observed that a higher number of PTC foci was associated with a tendency toward more aggressive features, including greater primary tumor size, more frequent extrathyroidal extension and cervical LNM.
Since the definition of an oligometastatic state of cancer, a paradigm shift toward more aggressive local control of primary tumor and/or small number of metastatic lesions and/or clinical LN relapse is gaining interest in many oncologic centres.
We discovered that GSCs in the recurrent tumor with malignancy progression were more aggressive than in the primary tumor, which suggests that tumor progression may be initiated early in tumor stem cells.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com