Sentence examples for more aggressive mutation from inspiring English sources

We studied the functional effects of the mutation K239N, which shows incomplete penetrance at the age of 65 years and compared it with the more aggressive mutation E120G.

It uses mutation with a higher-than-usual mutation probability to increase the exploration speed and crossover with the parent to repair losses incurred by the more aggressive mutation.

A more aggressive mutation of the virus, they said, could infect 30% to 50% of the population, lead to as many as 1.8 million hospitalizations and cause between 30,000 to 90,000 deaths compared to the annual number of 36,000.

Whereas this patient died at the age of 23, the only known reported patient with the same TARDBP mutation died at the age of 63 so it may simply be that the FUS mutation is the more "aggressive" mutation and they act independently such that we are seeing the end stage of the FUS-ALS disease and the earliest (if any) stage of the ALS-TDP disease [ 18].

As the more aggressive RET mutations are in codons 883 and 918, which are classified as level 3 (de Groot et al, 2006), we compared clinical data of somatic Met918Thr and Ala883Phe RET mutation cases (group 1; n=23, 45.1%) vs cases carrying other somatic RET mutations (group 2; n=19.619.6%), or having no RET mutation (group 3; n=18, 35.3%) (Table 3).

Waibel et al. found that cases of ALS-FUS with truncating mutations were associated with a more aggressive phenotype than missense mutations [ 16].

Another publication with reference to genetic and clinical, but not pathological analysis, has indicated that truncating mutations in the FUS gene may give rise to a more aggressive phenotype than missense mutations [ 16].

The more frequent the trauma, the more apt these cells are to develop aberrant DNA mutations; the more numerous the DNA mutations, the more aggressive the cancer [ 12].

Additionally, it was noted that even hemizygous loss of LKB1 in combination with KRAS resulted in a more aggressive phenotype than in KRAS mutation alone.

We have recently reported the presence of a higher copy number of the Grey mutation in more aggressive Grey horse melanomas [ 19], suggesting that the duplicated sequence may constitute a melanoma-driving element.

The association of the GNA11 mutation with another driver mutation in TERT might drive a more aggressive phenotype independently of chromosome 3 monosomy and BAP1 mutation.