Sentence examples for more aggressive mutant from inspiring English sources

Thorough RTK screening could reveal mutant RTKs with oncogenic phenotypes that are silent or masked by the presence of the more aggressive mutant EGFR.

In Drosophila, only one VAP gene is present and therefore its inactivation leads to the appearance of a more aggressive mutant phenotype (Pennetta et al., 2002; Forrest et al., 2013).

Using siRNA to inhibit CtBP expression, we have found that CtBPs are essential for the survival of breast cancer cells, and in particular those with a more aggressive p53-mutant phenotype.

The expression of serglycin was found to be relatively low in colon cancer cell lines and surprisingly was higher in low aggressive CACO-2 cells as compared to more aggressive HT-29 (mutant BRAF600V→T) and DLD-1 (mutant KRAS13G→D) colon cancer cells [ 20, 21]).

MET activation resulted in a more aggressive phenotype in MET mutant SCLC cells and its inhibition by PHA-665752 reversed this phenotype.

In another study, helical domain mutants produced a more aggressive phenotype than kinase domain mutants with regard to cellular motility and enhanced extravasation [ 29].

In the previous study, it was demonstrated that larger more aggressive tumours were observed in the double mutant PB Pten fl/fl Her2 KI mice compared with the wild-type and PB Pten fl/fl mice (Ahmad et al, 2011).

The present study represents a continuation of previous works in which we observed that lung carcinomas co-expressing MDM2 protein and p53 mutants (mt p53) exhibited more aggressive behaviour.

This is consistent with previous reports suggesting that overexpression of disease mutant TDP-43 results in a more aggressive phenotype than human WT TDP-43 expressed at comparable levels [ 38].

Homozygous FH (HoFH), the more aggressive and rare form of FH, results from two inherited mutant alleles of the defective gene resulting in cholesterol levels that are 3- to 6-fold higher than normal [ 3].

Mice with concurrent KRAS mutations and LKB1 inactivation have more aggressive tumours and a shorter survival than those with only KRAS mutant cancers (Ji et al, 2007).