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The fluid balance on the day before enrolment was almost 1 L higher in controls, possibly indicating a more aggressive initial volume replacement.
In view of the poorer outcome of these patients, perhaps they should be considered for more aggressive initial treatment.
More aggressive initial therapy may involve adding low-dose steroids, using combination DMARDs and the early use of biologics.
This could help identify a subset of patients who may benefit from a more aggressive initial treatment strategy than ADT alone, including combinations with novel drugs [ 103].
The savings in treatment and palliative care for advanced BC may be counterbalanced by the high costs of more aggressive initial treatment and longer follow-up [ 3, 4].
The preoperative identification of patients at increased risk of distant metastases enables a more aggressive initial staging strategy, facilitating the appropriate decision making regarding treatment options for this group of patients on early confirmation of metastatic disease.
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Ideally such cohorts include patients with severe and less severe disease, with more and less active RA, with more and less aggressive initial treatment.
When the crisis first broke in August 2007, the European Central Bank (ECB) was more aggressive in its initial response, providing at first unlimited cash to euro-zone banks.
But, come on, the shares could surely have been sold close to 400p if the government had not so obviously painted itself as a frustrated seller and if Moya Greene, Royal Mail's chief executive, could have been prodded to be a tad more aggressive with her initial dividend.
In an attempt to increase the percentage of people with HbA1c value at target recommendations, antihyperglycemic drug therapy has become more aggressive in recent years: initial treatment prescription of metformin (MET) associated to lifestyle changes is currently recommended by most international guidelines [7].
That work, followed by the expanded edition of 1581, provided a close comparison of the views of Aristotle and Plato on a wide range of philosophical issues, arguing that Plato's views were preferable on all counts (Kristeller 1964, 115), although it should be noted that the three books added to the 1581 edition exhibit a far more aggressive tone than the initial edition.
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more intensive initial
more aggressive economic
more negative initial
more radical initial
more appropriate initial
more relevant initial
more robust initial
more extreme initial
more rapid initial
more basic initial
more severe initial
more sensitive initial
more prominent initial
more neutral initial
more complex initial
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com