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Genetics Institute applied a "more aggressive" dosing regimen: consecutive intravenous daily injections of IL-12.
This calls into question the present approach to antibiotic dosing in these patients and supports use of more aggressive dosing strategies to minimize the likelihood of clinical failure.
At a dose of 10 mg/kg or higher, signs of toxicity were evident in infected animals (weight loss, lethargy), precluding more aggressive dosing regimens.
More aggressive dosing of all of the agents characterized could preserve their clinical utility, but this must be balanced with safety and tolerability issues by the physician.
This suggests that, while more aggressive dosing may enable a compound to kill more reliably (i.e., with a greater probability of success), this effect no longer holds once the potency of the agent has sufficiently eroded.
Furthermore, investigators may have employed more aggressive dosing in patients with infections that were perceived to be more severe due to prior antimicrobial treatment failure or multilobar involvement, both of which were more common in the higher vancomycin trough groups.
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This approach, which allows patients to feel in control, differs from traditional programs with forced, more aggressive dose tapering.
Anyone who does not advocate yet more aggressive doses of neo-liberalism – more privatisation, more cuts to the taxes of the wealthy, more attacks on workers' rights – is liable to come under suspicion, too.
The authors raise the possibility that more aggressive dose reduction could also be employed on the basis of adipose tissue volumes that could be derived from previous CT scans or from single-slice analysis in those without previous CTs.
Response rates were dose-dependent, with more aggressive doses yielding greater predicted response.
Toxicity concerns should not dissuade clinicians from more-aggressive doses because fluconazole is a very-well-tolerated drug with much higher doses successfully used without adverse effects [ 31].
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CEO of Professional Science Editing for Scientists @ prosciediting.com