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This study suggests a more aggressive diagnostic approach for patients with respiratory failure.
It has been suggested that this rise in AKI incidence is due to more aggressive diagnostic and therapeutic interventions in more recent years [ 5].
Ideally, biomarkers affect therapy by identifying patients likely to benefit from a therapeutic intervention or in whom a more aggressive diagnostic strategy should be undertaken.
Knowledge of potentially modifiable risk factors should help to identify those patients who might benefit from more aggressive diagnostic and/or therapeutic procedures [ 15].
Following the National Cancer Treatment Plans, a more aggressive diagnostic strategy has been implemented resulting in earlier diagnosis and thus an increased likelihood of curative treatment.
Its incidence is rising due to more aggressive diagnostic and therapeutic interventions in an ageing population with multiple comorbid diseases [ 3].
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Despite dismal survival in most patients, the possibility of long term survival should prompt more aggressive diagnostics in suspected PCNSL.
Despite dismal survival in most patients (median 2.3 months), the possibility of long term survival should prompt more aggressive diagnostics in suspected PCNSL.
Actually, the daily variations in PCT in addition to the clinical findings could be used as a surrogate to assess the effectiveness of therapy and to trigger more aggressive therapies and diagnostic investigations in an attempt to improve outcome.
Similar results were also observed in other human malignancies, such as esophageal, gastric, colon, and breast cancers [ 12, 16], in which the overexpression of the ATAD2 gene was often observed in more aggressive tumor subgroups and provided diagnostic value.
Our pilot data demonstrated that the majority of PrCa patients at UCH were diagnosed at an older age and had more aggressive clinical features (the median diagnostic PSA was 72.9 ng/ml, and 38% had a Gleason score of 8 10 tumor), in comparison to PrCa patients diagnosed in the US or other developed countries [ 2].
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more invasive diagnostic
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