Alternatively, IMRT/IGRT may facilitate EBRT dose-escalation of radiotherapy protocols and more aggressive combinations of radiotherapy with cytotoxic chemotherapy and/or novel systemic agents.
In addition, combination therapies with less supporting evidence, such as MTX plus antimalarials or MTX plus sulfasalazine [ 20], gradually disappeared as they were replaced by more aggressive combinations with better proven efficacy [ 18, 19, 21- 25].
Early use of more aggressive combination therapy, before responsiveness to monotherapy begins to decline, can be an effective approach [ 1, 15].
For example, because more aggressive combination treatments are more likely to be initiated in patients with uncontrolled blood pressure, it is likely that the beneficial treatment effects of such combination therapies will be underestimated.
Limitations of the currently recommended stepwise treatment pathway for type 2 diabetes mellitus (T2DM), especially the failure of monotherapies to maintain good glycemic control, have prompted use of early, more aggressive combination therapies.
These observations highlight the need to evaluate candidates for ixabepilone therapy on a case-by-case basis to determine whether the patient may experience the greatest overall benefit from monotherapy or from more aggressive combination therapy.
27 In contrast, the American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel recommends more aggressive, individualized combination therapy with a wider range of agents (eg, metformin, thiazolidinediones, incretin-based treatments, insulin) as initial pharmacotherapy for patients with T2DM to achieve HbA1c < 6.5%.
High MRP-1 cell membrane protein expression might be useful to identify those patients that are most likely to benefit from more aggressive treatment, combination treatment with standard chemotherapeutics and MRP-1 inhibitors, or treatment with a non-MRP-1 substrate (Roundhill and Burchill, 2012).
Results of the present study highlight the importance of understanding the potential for and frequency of host-switching between Euwallacea and members of the AFC, and that these shifts may bring together more aggressive and virulent combinations of these invasive mutualists.
The research sought to establish whether it was violence in games which made players feel more aggressive, or a combination of other factors.
This may be useful to identify patients requiring a transition to a more aggressive treatment or combination of treatments or even surgery.
