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Since HVA is an early metabolite of the catecholamine pathway, a VMA-to-HVA ratio of <1 suggests a more aggressive, biologically primitive type of NBL associated with a shorter survival [ 2, 4].
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This observation is contrary to conventional expectation that tumors enriched for stem cell properties would be biologically more aggressive.
BC in postmenopausal females may be biologically more aggressive.
Therefore, it is hypothesized that screen-detected DCIS is biologically more aggressive than interval DCIS.
Tumours arising in younger women appear to be biologically more aggressive and tend to have a poorer outcome.
In addition, hypoxia causes a differential expression profile which can lead to a biologically more aggressive and radioresistant phenotype.
Moreover, metastatic nodes in an unexpected site indicates that the primary tumour is biologically more aggressive [4].
TNBCs are biologically more aggressive, and chemotherapy remains the mainstay treatment option in the neoadjuvant, adjuvant and metastatic setting.
Two patients had HCC that was biologically more aggressive and similar to patients with elevated serum CA19-9.
Although SCC and SGC are less common than BCC, they may behave biologically more aggressive and are potentially lethal tumors.
Proximal lesions are in fact biologically more aggressive and have a worse prognosis (stage for stage) than distal gastric cancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com