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Apparently this feature is associated with more aggressive biological behaviour and could be used to identify women who are at higher risk of recurrence.
Dysregulation of the hepatocyte growth factor (HGF /MET pathway is associated with poor prognosis, more aggressive biological characteristics of the tumor, and shortened survival in patients with metastatic colorectal cancer (mCRC).
Occasionally, this periosteal reaction may show a sunburst appearance, suggesting a more aggressive biological behaviour.
Pleomorphic lobular carcinoma in situ (PLCIS) is an example of a new entity with a more aggressive biological behaviour that may exhibit apocrine or histiocytic differentiation and signet ring cells.
As for uterine cervical cancer, a large amount of evidences demonstrate that elevated levels of EGFR are closely relevant to a more aggressive biological behavior and further to poor prognosis in cervical cancer patients clinically [20], making EGFR an attractive candidate for anti-cancer therapy.
In addition, they were associated with clinical presentation at a younger age (<3 years of age) and more aggressive biological behavior with an increased risk of metastases at the time of diagnosis.
Similar(20)
Invasive pituitary adenomas were described as being more aggressive in biological behavior and showing an increased growth rate compared to that of non-invasive tumors [ 36, 48, 52].
Advanced disease stage may represent a more aggressive tumour biological behaviour with higher metabolic demands and a propensity for increased cell turnover and energy consumption.
In our series, BRCA1 promoter hypermethylation was found in 18 tumours and was significantly associated with a more aggressive clinico-biological profile and with triple negativity.
These collective findings suggest that tumors arising in younger patients may be more aggressive due to biological differences.
The results of this study do not verify that oral BSCCs have a more aggressive clinical and biological behavior than oral SCCs.
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