Sentence examples for more aggressive biologic from inspiring English sources

Central CS of the axial skeleton showed more aggressive biologic behavior than appendicular tumors, and high incidence of local recurrence after intralesional excision of grade 1 CS of the axial skeleton was reported [5, 9, 10, 24].

The immunohistochemical profile of the studied cysts clearly showed that OOC presents a well-formed cystic enveloping, whereas the OKC profile is compatible with a more aggressive biologic behavior.

Young patients often present with more aggressive biologic behavior, such as advanced stage, less ER positive expression, higher histological grade and more lymph-vascular invasion [ 15].

Nod 1 and Nod 8, which clustered close to the infiltrative tumors, were the largest in their class, perhaps indicating more aggressive biologic behavior.

We therefore hypothesise that the occurrence of an asymptomatic VTE seems to be an expression of an advanced stage or associated with a more aggressive biologic behaviour of the malignant disease.

Our results are consistent with some previous studies [ 42, 46] which showed that Rb negative tumors had a more aggressive biologic behavior with decreased patients' survival, and more liability to tumor progression than positive ones.

Not only do these "receptor-negative" breast cancers fail to benefit from current hormonal therapies, but they also generally exhibit more-aggressive biologic behaviors and poorer prognosis than the receptor-positive ones [ 10- 14].

HCV-patients with RA often require more aggressive therapy, including biologics, which also have to be used with caution.

2, 5, 6 These data have prompted an awareness and interest in more aggressive management of psoriasis including biologic agents.

Patients with more advanced MF/SS or those who relapse and become resistant to initial treatments require a more aggressive therapeutic approach, which may involve biologic response modifiers, combination therapies, bone marrow transplantation, or chemotherapy.

Furthermore, due to the chronic nature of RA and the increasing emphasis on earlier and more aggressive treatment, patients are likely to receive biologic therapy for extended periods of time (1, 6).