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For a proportion of patients a genetic predisposition has been hypothesized as 2% to 7% of patients have one or more affected relatives [3].
Having two or more affected relatives was associated with a 2.69 5.40-fold risk increase.
Such risks seem to be cumulative, with two or more affected relatives conferring greater risk [11].
Having two or more affected relatives showed higher risks of all three UGI cancers.
Men with two or more affected relatives are at even higher risk.
We found that most families were cancer free, and a minority included two or more affected relatives.
Similar(42)
Therefore exp(β i ) is the ratio of the odds for being a mutation carrier comparing a woman with the ith characteristic with one without that characteristic, or having one more affected relative, given that the two women are the same for all other characteristics.
Assuming that women who reported that they had only sister(s) or only daughter(s) with breast cancer were recorded as having one affected first-degree relative, we recategorized our information on family history to three categories of 0, 1, or 2 or more affected first-degree relatives.
Individuals with two or more affected first-degree relatives had 10-fold increased ESCC risk.
We described and evaluated a prediction model for individuals with one or more affected first-degree relatives.
The formula subsequently includes the information on ovarian cancer, bilateral breast cancer and more than two affected relatives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com