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All of the infected budgerigars developed changes typical of mycobacteriosis, but more advanced pathological changes were visible in the group infected with the pheasant isolate.
Significantly higher expression levels of miR-375 were depicted in patients with higher Gleason score and more advanced pathological stage, as well as with regional lymph nodes metastases.
Furthermore, higher expression levels associated with higher Gleason score and more advanced pathological stage, two clinicopathological parameters that entail unfavorable prognosis.
MiR-375 expression levels were significantly higher in cases with higher Gleason score and more advanced pathological stage at diagnosis (P < 0.05, P < 0.001, Figure 1B, C).> -wrap-foot>> -wrap-foot> *Passanger strand.
Validation in two large independent sets of patients demonstrated that miR-375 expression was increased in PCa with higher Gleason score and more advanced pathological stage, which entail worse prognosis.
Several studies have also found that in clinically localized prostate cancer a low pretreatment serum T is associated with a more advanced pathological stage and increases the probability of non-organ confined disease [ 93- 95].
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All infected budgerigars developed signs typical of mycobacteriosis, but more advanced clinical and pathological changes were visible in the group infected with the pheasant isolate.
In a very recent report on breast cancer, obese patients presented with larger, more advanced tumors and aggressive cancer pathological features, including lymph node metastases, advanced tumor stage, and high grade [ 2].
20 In addition, more advanced skills and technology for pathological diagnosis, such as basic immunohistochemical analysis, should be introduced whenever feasible in tertiary hospitals around the country.
If a subject had more than one polyp, the most advanced pathological lesion or the largest lesion was included in the analysis.
Another human HCC dataset (GSE6764) included more advanced HCC stages, in which the pathological HCC stages were defined by tumor size, differentiation status and metastasis level (Wurmbach et al., 2007).
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