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Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently because the injected cells undergo apoptosis.
In 1988 came the first federal ban when the first President Bush barred implanting humans with fetal tissue (fetuses are far more advanced in development than microscopic embryos).
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"It appears that, so far, the places in reception at free primary schools are being filled by children who are somewhat less disadvantaged and more advanced in their development than the average.
More advanced in the development is the novel oral fluoroketolide solithromycin (family: macrolides) that has proved to have a high activity against gonococci, including azithromycin-resistant, ESC-resistant and MDR isolates [ 132].
Separating patient groups at the 2nd cIMT measurement according to Tanner stages in early- or midpubertal (n = 28) and late or postpubertal patients (n = 42), those more advanced in pubertal development had a much higher mean increase in cIMT-z-scores than younger patients (0.80 ± 0.70 vs. 0.27 ± 0.70 SD, p < 0.05).
These advances are an important consideration for the development of more advanced in vitro model systems for studying chemical-induced hepatotoxicity, toxicity pathway perturbations, and networks of interactions among various cell types.
The nephrons found in the kidneys (mesonephros) of amphibians and most fish, and in the late embryonic development of more advanced vertebrates, are only slightly more advanced in structure.
Or more advanced in their manufacturing?
Our results support observations suggesting more advanced development in girls [ 32].
This is a baseline examination in a longitudinal prospective study, and though the results indicate more advanced atherosclerotic development in the diabetic group, it is reassuring that the changes are small in this group of young patients at this early stage of the disease.
However, once the number of ACF increased to the maximum value observed in this study (~70), the measured increase of the nuclear diameter was specific to the region manifesting more advanced neoplastic development, in contrast to the ubiquitous and relatively constant cell nuclear diameter measurements of the plateau region.
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