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Furthermore, this BBB defect in the rTg4510 mouse model can now be used to more adequately model the pharmacokinetic profile of promising pre-clinical therapies to treat tauopathies, since BBB dysfunction is found in AD, traumatic brain injury (TBI) and other tauopathies.
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While the linear regression model is simple (to run and interpret), elegant and efficient, many interesting processes may be more adequately modeled by non-linear models in practice.
It has been shown that materials with memory and hereditary effects and dynamical processes including gas diffusion and heat conduction can be more adequately modeled by fractional differential equations (FDEs) than by integer-order differential equations [3, 4].
Our conservative estimate of cost-effectiveness, while in contradiction to other published analyses, nevertheless more adequately models the known long-term efficacy data for this drug.
An electrical equivalent circuit corresponding to the Voight model, which describes the behavior of the passive film on tin more adequately than the models for 'classical' semiconductors, is presented.
Notably, often more than one model can fit the data equally well, because they will handle different evolutionary properties more adequately (for example codon structure or non-stationarity of nucleotide composition).
Hence, in this article we formulate two different switching models more adequately and examine their behaviour and the nature of the different regimes in the US gasoline market.
As evidence has accumulated from various regions across the globe, the ideological model has more adequately accommodated diverse styles and uses of literacy.
A year-long model may more adequately prepare the new teacher in terms of their self-esteem and experience at tackling the everyday tasks.
In contrast, a components-based model may more adequately explain heterogeneity in the included interventions, but may say little about the interventional mechanisms at play and may thus be of lesser utility.
The reason we consistently use lysate activities throughout the paper is that this is what was the basis for the selection of improved variants in our screens and therefore more adequately reflects "fitness" in our model evolutionary system, as mentioned in the text (subsection "Phenotypic reversibility in the laboratory evolution of PTE").
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