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Six (12%) patients reported a more acute onset with symptoms developing during a few hours.
A more severe approach leads to the development of overt organ failure [ 48, 77], but results in high mortality rates [ 78] and more acute onset of the heart failure substrate.
Our results suggest that that SIP is associated with more acute onset due to a proximal trigger (substance misuse) and that more severe symptoms propel patients into care more rapidly.
Anti-CII-positive patients also have more joint destructions and a shorter time from symptom onset to clinical RA diagnosis, further arguing for a more acute onset among these patients [ 1, 2].
PMR was evaluated using the definition of Gajdusek et al 1 2 that PMR is a subacute paralytic condition reminiscent of Landry Guillain Barré syndrome, which combines radicular, or perhaps neuritic, elements with more acute onset and sometimes asymmetric paralysis.
The presence of diabetic ketoacidosis at diabetes onset was nonsignificantly greater among youth with type 1 diabetes (40 vs. 14.3% in type 2 diabetes), suggesting a more acute onset possibly caused by more aggressive etiopathogenesis.
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Subjects lost to follow-up were younger (mean difference of 7 years) and showed more often an acute onset (47% versus 37%).
In a number of the patients first admittance to hospital was not necessarily due to problems with ongoing treatment, but due to a more acute or dramatic onset of symptoms of schizophrenia.
As subjects lost to follow-up showed more often an acute onset (47% versus 37%), were younger (mean difference of 7 years) and the variable age is included in the MI model for the outcome measure persistent shoulder disability, it is plausible to assume that these missings are MAR.
Moreover, remission was more in patients with acute onset and good adherence to drugs.
All these variables are presented in table 5. Comparison of remittent to non remittent patients showed statistically significant differences as remission was more with cases of acute onset of illness and good adherence to drugs.
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