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While severe lupus requires addition of more active therapeutic agents, the current recommendation is for use of this drug throughout the course of disease.
The reason that patients with a myocardial infarction have fewer visits, is likely to be related to the more active therapeutic approach adopted since 1987.
There is a trend towards earlier diagnosis and more active therapeutic interventions in the treatment of COPD to prevent the development of disabling disease [ 39].
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These data demonstrate that GZ25 is a stable synthetic retinoid with improved activity which efficiently regulates neuronal differentiation and help to define the key structural requirements for retinoid activity enabling the design and development of the next generation of more active, selective synthetic retinoids as potential therapeutic regulators of neurogenesis.
Thus, the new therapeutic agents needed should be more active and produce fewer side effects and they also should act through a mechanism different from that of cytotoxic agents already used.
It has been demonstrated that both the steric and electrostatic factors should appropriately be taken into account in future rational design and development of more active and more selective PDE5 inhibitors for the therapeutic treatment of erectile dysfunction (ED).
This reduces secondary effects risk of long-term use and leaves therapeutic margin if disease gets more active later.
There are more active clinical trials ongoing than ever before and many investigators are optimistic that new preventive and therapeutic options will emerge over the next decade [ 6, 7].
This finding represents an advantage in the use of BM-MSCs; the more active the cell, the more extracellular matrix it produces, thus promoting bone regeneration when used for therapeutic purposes.
The diacetyl derivative of l-dopa amide (11b) was found to be more active than l-dopa after its oral administration and generated plasma levels of l-dopa in the therapeutic range for an antiparkinsonian effect in man.
This may be a reflection of a positive therapeutic alliance as a result of a person-centred holistic approach that leads to a more active patient [ 53, 65].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com