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One possibility is that use of more oral agents reflected more active glucose management, and this continued in respect of insulin dose adjustment during the study.
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It is perhaps easier to think of GI neurons as those glucose-sensing neurons that become more active when glucose levels fall, and as such they may use signaling mechanisms more relevant to the pancreatic α-cell.
The most active variant, identified after only one round of diversification and screening of only 10,000 wells, is approximately 400-fold more active on glucose than is the wild-type enzyme.
However, plasma glucose does not depend on the hematocrit value and reflects active glucose more faithfully.
Finally, the bitransgenic tumours were metabolically more active as indicated by increased glucose transporter 1 (GLUT1) expression, elevated lactate production and decreased intracellular glucose (suggesting increased glycolysis).
We report for the first time a soluble PQQ glucose dehydrogenase that is twice more active than the wild type for glucose oxidation and was obtained by combining site directed mutagenesis, modelling and steady-state kinetics.
On the other hand, D-ribose is an efficient glycator (Chen et al., 2009, 2010; Wei et al., 2009) and is much more active in protein glycation than D-glucose under identical conditions.
Yet the brain's olfactory centres consumed more glucose (and were thus more active) when the steroid was present in the clove oil than when it was absent.
Glucose-6-phosphate dehydrogenase (G6PDH) was more active than malic enzyme (ME) in lipid accumulation stage and showed higher activities in NaNO3 than other N-sources.
However, this finding must be investigated further because greater Reg1p-Snf1p isteractiobservedserved in low-glucose conditions when Snf1p is more active [53].
The cyclic voltammetry and chronoamperometry of the prepared catalysts point out that PtAu/C is more active and stable than PtBi/C and commercial PtRu/C towards glucose electro-oxidation in alkaline medium.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com