Sentence examples for more active derivatives from inspiring English sources

The relatively simple structure of ellipticine has prompted chemists to design various structural modifications in order to obtain either more active derivatives or information on the structural moieties required for pharmacological activities.

Acute in vivo toxicity of two of the more active derivatives was evaluated.

A detailed understanding of the chemical/biochemical aspects of such interactions with DNA is expected to provide the necessary insight to design new generations of more active derivatives.

Nalidixic acid and its more active derivatives, the fluoroquinolones, were rarely used in Africa before the late 1990s because of their high cost.

The duplication of the pharmacophore leads to an equivalent or more active derivative, which exhibits a different selectivity profile and pharmacokinetic properties.

For compound 2, the presence of a pyrrolidinium ring on the fullerene carbon cage brought to a more active derivative unlike the corresponding fulleropyrrolidine.

Nonetheless, the highly charged drug fosmidomycin and its more active methyl-derivative FR900098 have proven parasiticidal activity against erythrocytic stages of the malaria parasite Plasmodium falciparum.

The results show that the derivatives containing benzothiazole moiety are more active than the derivatives containing oxazole moiety.

These compounds revealed realistic Shikimate Kinase inhibitory activity and can be more active to design derivatives with modified actions.

An open question is whether these chemicals transform into potentially more active or toxic derivatives via xenobiotic metabolizing enzymes expressed in the body.

Indeed, the desmethyl urea lipids in particular exhibited very strong activity against Leishmania donovani and were in fact at least 10 times more active than the methylated derivatives (Table S2).