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Consistent with these dynamics, the kinetic pathway can be separated into two parts: (1) the time it takes to form active conformations and the search time from less active to more active conformations and (2) the actual traversal from substrate to product.
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We can speculate that a serine residue, with a negatively charged hydroxy-containing side chain and less conformational flexibility might 'lock' the kinase in a more active conformation.
This means that the gp91phox 221-C protembeddeddded into natural lipids is folded in a more active conformation in comparison to the detergent-soluble protein.
Since organic immobilization may preserve a more active conformation of trypsin compared to the aqueous method, this effect may be more prominent in the synthesis reaction.
It is tempting to speculate that LOXL2i-Snail1 interaction prompts Snail1 to adopt a more active conformation with enhanced DNA binding ability as suggested by the DAPA analysis.
Walking is more active form of meditation.
Interactions with the hydrophobic surfaces of nanotubes are expected to result in the 'open lid', as well as more active lipase conformations.
Knowledge of more active agonist conformations may assist in determining which other residues in the human receptors are necessary for this property.
This insight suggests a more active NOX conformation at high temperatures, resulting in higher affinity for the flavin cofactor.
Our results build on this model of cargo capture to suggest that coat-adaptors may have more than two active conformations influenced by different Arf proteins.
As we will see, these lipids play a more active role in the conformation, oligomerisation and aggregation of amyloidogenic proteins than just acting as a concentration platform.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com