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Therefore, the search for less toxic and more active combination chemotherapy regimens in pretreated oesophageal cancer remains justified within clinical trials.
As studies demonstrate that CQ and HCQ are equipotent autophagy inhibitors, and based on its safer toxicity profile, we chose HCQ for a dose-escalation study., We cannot, however, exclude the possibility that TMZ, RT, and CQ would have proven to be a more active combination.
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If this pairing would be thermodynamically more preferred than pairing of two active components, then removal of the inactive component would lead to re-equilibration in favor of the more active catalyst combination and thus increased rates.
The results of these trials, therefore, justify the continuing search for new drugs or more active drug combinations.
A single formulation of a fixed dose of two drugs has been described as part of an ideal profile for anti-malarial drug combinations and recently a hybrid compound derived from mefloquine and artesunate has been reported to be more active than a combination of both single drugs against the malaria parasite.
Quality of life had improved more with the active combination than with the vehicle combination.
While we see Beurden bringing continuity - we do not see scope for a strategic revolution - we do believe that the combination of more active disposals, a more shareholder friendly approach with increasing distributions and more capital discipline could get the stock going.
Quercetin was found to be more active than M + R combination.
The hypothesis that the combination is more active than single-agent DAC will be investigated in a randomized setting.
In Calu-3, BT-474 and SK-BR-3 cells, T-DM1 was more active than pertuzumab and the combination was more potent than the single drugs.
This effect was similar to that of TNF-α and their combination was more active, inducing migration of 131 cells/field.
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